Enables peptide chain release factor N(5)-glutamine methyltransferase activity. Predicted to be involved in translational termination. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HEMK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HEMK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HEMK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:50,275,163–50,276,639 | 293.0 kb | Distal (>10kb) Multiome | 151 | |
| chr3:50,291,628–50,292,796 | 277.0 kb | Distal (>10kb) Multiome | 855 | |
| chr3:50,298,495–50,300,110 | 270.0 kb | Distal (>10kb) Multiome | 872 | |
| chr3:50,303,363–50,303,840 | 265.8 kb | Distal (>10kb) Multiome | 484 | |
| chr3:50,320,603–50,322,739 | 247.9 kb | Distal (>10kb) Multiome | 816 | |
| chr3:50,324,456–50,325,020 | 244.7 kb | Distal (>10kb) Multiome | 392 | |
| chr3:50,327,933–50,328,581 | 241.2 kb | Distal (>10kb) Multiome | 697 | |
| chr3:50,336,856–50,338,227 | 231.9 kb | Distal (>10kb) Multiome | 952 | |
| chr3:50,340,624–50,341,322 | 228.5 kb | Distal (>10kb) Multiome HiCAR | 345 | |
| chr3:50,345,443–50,346,042 | 223.7 kb | Distal (>10kb) Multiome HiCAR | 209 | |
| chr3:50,350,496–50,351,298 | 218.5 kb | Distal (>10kb) Multiome HiCAR | 902 | |
| chr3:50,358,889–50,360,012 | 209.9 kb | Distal (>10kb) Multiome HiCAR | 796 | |
| chr3:50,364,552–50,365,867 | 204.2 kb | Distal (>10kb) Multiome HiCAR | 331 | |
| chr3:50,435,932–50,436,533 | 133.3 kb | Distal (>10kb) Multiome HiCAR | 248 | |
| chr3:50,502,505–50,504,160 | 65.8 kb | Distal (>10kb) Multiome | 312 | |
| chr3:50,567,311–50,568,123 | 1.7 kb | Proximal (<10kb) Multiome | 376 | |
| chr3:50,568,824–50,569,934 | 176 bp | At TSS Multiome | 901 | |
| chr3:50,572,177–50,572,379 | 3.0 kb | Proximal (<10kb) | 230 | |
| chr3:50,611,315–50,612,530 | 42.5 kb | Distal (>10kb) Multiome | 904 | |
| chr3:50,615,997–50,617,867 | 47.6 kb | Distal (>10kb) Multiome | 754 | |
| chr3:50,674,463–50,675,603 | 105.7 kb | Distal (>10kb) Multiome | 344 | |
| chr3:51,384,278–51,385,586 | 815.6 kb | Distal (>10kb) Multiome HiCAR | 787 | |
| chr3:51,499,159–51,500,640 | 930.6 kb | Distal (>10kb) Multiome HiCAR | 838 | |
| chr3:51,941,340–51,942,909 | 1372.6 kb | Distal (>10kb) Multiome HiCAR | 890 | |
| chr3:51,982,506–51,983,633 | 1413.8 kb | Distal (>10kb) Multiome HiCAR | 933 |
Genomic view of the HEMK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.