Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HECTD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HECTD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HECTD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:91,162,157–91,164,240 | 246.2 kb | Distal (>10kb) Multiome | 793 | |
| chr10:91,220,219–91,221,432 | 188.6 kb | Distal (>10kb) Multiome | 831 | |
| chr10:91,297,921–91,299,237 | 110.8 kb | Distal (>10kb) Multiome | 528 | |
| chr10:91,409,159–91,411,261 | 1.0 kb | At TSS Multiome | 903 | |
| chr10:91,414,698–91,415,115 | 5.4 kb | Proximal (<10kb) | 113 | |
| chr10:91,632,611–91,633,844 | 223.9 kb | Distal (>10kb) Multiome | 874 |
Genomic view of the HECTD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.