Enables ubiquitin protein ligase activity. Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within several processes, including chordate embryonic development; circulatory system development; and protein ubiquitination. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HECTD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HECTD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HECTD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:31,025,320–31,027,211 | 181.2 kb | Distal (>10kb) Multiome | 1060 | |
| chr14:31,038,509–31,039,198 | 169.0 kb | Distal (>10kb) Multiome | 498 | |
| chr14:31,059,276–31,059,946 | 148.0 kb | Distal (>10kb) Multiome | 491 | |
| chr14:31,060,184–31,060,800 | 147.3 kb | Distal (>10kb) Multiome | 152 | |
| chr14:31,206,827–31,208,656 | 86 bp | At TSS Multiome | 1146 | |
| chr14:31,419,762–31,421,044 | 212.8 kb | Distal (>10kb) Multiome | 1119 | |
| chr14:31,456,819–31,457,870 | 249.6 kb | Distal (>10kb) Multiome | 1008 |
Genomic view of the HECTD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.