The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. [provided by RefSeq, May 2016]
Transcription factors with Perturb-seq knockdown data for HEBP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HEBP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HEBP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:138,105,499–138,106,672 | 298.0 kb | Distal (>10kb) Multiome HiCAR | 557 | |
| chr6:138,106,898–138,108,486 | 296.6 kb | Distal (>10kb) Multiome HiCAR | 878 | |
| chr6:138,160,942–138,162,612 | 242.4 kb | Distal (>10kb) Multiome | 699 | |
| chr6:138,240,458–138,241,750 | 163.0 kb | Distal (>10kb) Multiome | 180 | |
| chr6:138,331,206–138,332,418 | 72.6 kb | Distal (>10kb) Multiome | 260 | |
| chr6:138,403,215–138,405,244 | 2 bp | At TSS Multiome | 1060 | |
| chr6:138,485,936–138,486,779 | 82.0 kb | Distal (>10kb) Multiome | 199 | |
| chr6:138,691,712–138,693,955 | 289.1 kb | Distal (>10kb) Multiome | 807 |
Genomic view of the HEBP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.