The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for HEBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HEBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HEBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:12,716,729–12,717,910 | 283.0 kb | Distal (>10kb) Multiome | 799 | |
| chr12:12,723,708–12,726,164 | 274.6 kb | Distal (>10kb) Multiome | 958 | |
| chr12:12,786,507–12,787,490 | 213.2 kb | Distal (>10kb) Multiome | 739 | |
| chr12:12,812,936–12,813,661 | 187.0 kb | Distal (>10kb) Multiome | 700 | |
| chr12:12,999,403–13,001,860 | 1.4 kb | Proximal (<10kb) Multiome | 719 | |
| chr12:13,044,080–13,044,940 | 44.2 kb | Distal (>10kb) Multiome | 620 | |
| chr12:13,100,982–13,102,043 | 101.1 kb | Distal (>10kb) Multiome | 629 | |
| chr12:13,255,750–13,256,547 | 255.8 kb | Distal (>10kb) Multiome | 625 | |
| chr12:13,278,080–13,278,892 | 278.2 kb | Distal (>10kb) Multiome | 312 |
Genomic view of the HEBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.