Enables enzyme binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for HDHD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HDHD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HDHD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:46,916,768–46,918,244 | 233.0 kb | Distal (>10kb) Multiome | 715 | |
| chr18:46,946,455–46,947,310 | 203.7 kb | Distal (>10kb) Multiome | 249 | |
| chr18:47,149,543–47,151,037 | 113 bp | At TSS Multiome | 824 | |
| chr18:47,175,919–47,176,532 | 25.8 kb | Distal (>10kb) Multiome | 731 | |
| chr18:47,246,981–47,248,546 | 97.1 kb | Distal (>10kb) Multiome | 158 | |
| chr18:47,254,445–47,254,917 | 104.2 kb | Distal (>10kb) Multiome | 213 | |
| chr18:47,260,995–47,261,741 | 111.0 kb | Distal (>10kb) Multiome | 93 | |
| chr18:47,263,134–47,264,324 | 113.1 kb | Distal (>10kb) Multiome | 151 |
Genomic view of the HDHD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.