The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for HDAC10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HDAC10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HDAC10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:49,959,889–49,961,612 | 290.8 kb | Distal (>10kb) Multiome | 843 | |
| chr22:49,961,773–49,962,968 | 288.8 kb | Distal (>10kb) Multiome | 708 | |
| chr22:49,999,173–50,000,437 | 251.6 kb | Distal (>10kb) Multiome | 237 | |
| chr22:50,030,288–50,030,739 | 220.8 kb | Distal (>10kb) Multiome | 433 | |
| chr22:50,169,918–50,170,446 | 81.0 kb | Distal (>10kb) Multiome | 245 | |
| chr22:50,184,288–50,186,776 | 65.4 kb | Distal (>10kb) Multiome | 542 | |
| chr22:50,199,706–50,201,679 | 50.3 kb | Distal (>10kb) Multiome | 612 | |
| chr22:50,244,340–50,245,635 | 6.2 kb | Proximal (<10kb) Multiome | 868 | |
| chr22:50,247,828–50,248,046 | 3.2 kb | Proximal (<10kb) | 154 | |
| chr22:50,250,480–50,251,917 | 113 bp | At TSS Multiome | 683 | |
| chr22:50,252,224–50,252,418 | 982 bp | At TSS | 229 | |
| chr22:50,261,070–50,261,932 | 10.4 kb | Distal (>10kb) Multiome | 512 | |
| chr22:50,267,469–50,268,208 | 16.5 kb | Distal (>10kb) Multiome | 196 | |
| chr22:50,299,702–50,300,750 | 49.2 kb | Distal (>10kb) Multiome | 250 | |
| chr22:50,307,140–50,307,760 | 56.3 kb | Distal (>10kb) Multiome | 392 | |
| chr22:50,326,615–50,327,631 | 75.8 kb | Distal (>10kb) Multiome HiCAR | 754 | |
| chr22:50,342,153–50,342,608 | 91.3 kb | Distal (>10kb) Multiome | 553 | |
| chr22:50,342,772–50,343,603 | 92.0 kb | Distal (>10kb) Multiome | 573 | |
| chr22:50,474,348–50,475,571 | 223.9 kb | Distal (>10kb) Multiome | 487 | |
| chr22:50,481,062–50,482,150 | 230.3 kb | Distal (>10kb) Multiome | 387 | |
| chr22:50,506,343–50,508,710 | 256.7 kb | Distal (>10kb) Multiome | 856 | |
| chr22:50,524,965–50,527,480 | 275.9 kb | Distal (>10kb) Multiome | 1031 | |
| chr22:50,529,065–50,532,692 | 279.7 kb | Distal (>10kb) Multiome | 745 |
Genomic view of the HDAC10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.