Transcription factors with Perturb-seq knockdown data for HCG15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HCG15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HCG15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:28,977,296–28,977,786 | 8.4 kb | Proximal (<10kb) | 157 | |
| chr6:28,980,730–28,982,814 | 3.4 kb | Proximal (<10kb) | 914 | |
| chr6:28,984,693–28,985,963 | 239 bp | At TSS | 553 | |
| chr6:28,988,531–28,989,268 | 2.3 kb | Proximal (<10kb) | 290 |
Genomic view of the HCG15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.