HAUS1 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]
Transcription factors with Perturb-seq knockdown data for HAUS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HAUS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HAUS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:45,828,904–45,829,753 | 275.0 kb | Distal (>10kb) Multiome | 246 | |
| chr18:45,837,425–45,838,195 | 266.6 kb | Distal (>10kb) Multiome | 298 | |
| chr18:45,966,885–45,967,828 | 137.0 kb | Distal (>10kb) Multiome | 738 | |
| chr18:46,071,357–46,072,732 | 32.1 kb | Distal (>10kb) Multiome | 481 | |
| chr18:46,088,381–46,089,449 | 15.6 kb | Distal (>10kb) Multiome | 165 | |
| chr18:46,097,820–46,098,847 | 6.0 kb | Proximal (<10kb) Multiome | 879 | |
| chr18:46,104,121–46,104,853 | 8 bp | At TSS Multiome | 704 | |
| chr18:46,113,840–46,114,096 | 9.5 kb | Proximal (<10kb) | 92 | |
| chr18:46,173,230–46,174,989 | 69.4 kb | Distal (>10kb) Multiome | 936 | |
| chr18:46,246,205–46,246,709 | 142.1 kb | Distal (>10kb) Multiome | 36 | |
| chr18:46,281,044–46,282,187 | 177.1 kb | Distal (>10kb) Multiome | 176 | |
| chr18:46,283,349–46,284,427 | 179.6 kb | Distal (>10kb) Multiome | 234 | |
| chr18:46,333,344–46,334,272 | 229.6 kb | Distal (>10kb) Multiome | 327 | |
| chr18:46,335,534–46,336,092 | 231.3 kb | Distal (>10kb) Multiome | 192 |
Genomic view of the HAUS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.