Predicted to enable metal ion binding activity and nuclease activity. Located in centriolar satellite; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for HARBI1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HARBI1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HARBI1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:46,338,698–46,339,679 | 278.0 kb | Distal (>10kb) Multiome | 393 | |
| chr11:46,346,987–46,348,092 | 269.8 kb | Distal (>10kb) Multiome | 586 | |
| chr11:46,352,002–46,352,557 | 264.9 kb | Distal (>10kb) Multiome | 306 | |
| chr11:46,379,120–46,383,444 | 237.6 kb | Distal (>10kb) Multiome | 930 | |
| chr11:46,388,459–46,390,750 | 228.4 kb | Distal (>10kb) Multiome | 593 | |
| chr11:46,391,139–46,393,221 | 224.5 kb | Distal (>10kb) Multiome | 965 | |
| chr11:46,407,311–46,408,466 | 209.3 kb | Distal (>10kb) Multiome | 157 | |
| chr11:46,554,280–46,555,184 | 62.5 kb | Distal (>10kb) Multiome | 531 | |
| chr11:46,593,562–46,594,345 | 23.2 kb | Distal (>10kb) Multiome | 845 | |
| chr11:46,616,855–46,618,064 | 79 bp | At TSS Multiome | 823 | |
| chr11:46,664,502–46,665,016 | 47.6 kb | Distal (>10kb) Multiome | 126 | |
| chr11:46,674,791–46,675,556 | 57.9 kb | Distal (>10kb) Multiome | 308 | |
| chr11:46,700,262–46,701,275 | 83.5 kb | Distal (>10kb) Multiome | 997 | |
| chr11:46,826,562–46,827,053 | 209.7 kb | Distal (>10kb) Multiome | 529 | |
| chr11:46,845,538–46,846,680 | 229.0 kb | Distal (>10kb) Multiome | 879 | |
| chr11:46,912,540–46,913,271 | 295.6 kb | Distal (>10kb) Multiome | 252 |
Genomic view of the HARBI1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.