This gene belongs to the hyaluronan and proteoglycan binding link protein gene family. The protein encoded by this gene may function in hyaluronic acid binding and cell adhesion. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for HAPLN3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HAPLN3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HAPLN3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:88,604,930–88,605,917 | 289.8 kb | Distal (>10kb) Multiome | 530 | |
| chr15:88,610,494–88,611,216 | 284.6 kb | Distal (>10kb) Multiome | 201 | |
| chr15:88,612,843–88,613,762 | 282.2 kb | Distal (>10kb) Multiome | 214 | |
| chr15:88,614,278–88,615,021 | 280.8 kb | Distal (>10kb) Multiome | 414 | |
| chr15:88,620,659–88,621,775 | 274.3 kb | Distal (>10kb) Multiome | 829 | |
| chr15:88,638,306–88,639,588 | 256.6 kb | Distal (>10kb) Multiome | 1000 | |
| chr15:88,802,773–88,804,052 | 92.0 kb | Distal (>10kb) Multiome | 209 | |
| chr15:88,884,728–88,885,208 | 10.6 kb | Distal (>10kb) Multiome | 118 | |
| chr15:88,894,331–88,895,700 | 945 bp | At TSS Multiome | 400 | |
| chr15:88,904,638–88,905,279 | 9.1 kb | Proximal (<10kb) | 420 | |
| chr15:88,912,215–88,913,629 | 17.8 kb | Distal (>10kb) Multiome | 632 | |
| chr15:88,985,799–88,986,383 | 90.7 kb | Distal (>10kb) Multiome | 269 | |
| chr15:88,998,974–88,999,579 | 103.7 kb | Distal (>10kb) Multiome HiCAR | 139 | |
| chr15:89,017,417–89,018,078 | 122.2 kb | Distal (>10kb) Multiome HiCAR | 478 | |
| chr15:89,087,643–89,089,226 | 192.8 kb | Distal (>10kb) Multiome | 898 |
Genomic view of the HAPLN3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.