The enzyme encoded by this gene is classified as a thiolesterase and is responsible for the hydrolysis of S-lactoyl-glutathione to reduced glutathione and D-lactate. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Transcription factors with Perturb-seq knockdown data for HAGH. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HAGH upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HAGH, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:1,610,035–1,611,264 | 216.2 kb | Distal (>10kb) Multiome | 745 | |
| chr16:1,611,870–1,612,834 | 214.6 kb | Distal (>10kb) Multiome | 718 | |
| chr16:1,677,899–1,679,024 | 148.6 kb | Distal (>10kb) Multiome | 709 | |
| chr16:1,705,380–1,706,702 | 120.7 kb | Distal (>10kb) Multiome | 933 | |
| chr16:1,763,511–1,764,353 | 62.8 kb | Distal (>10kb) Multiome | 261 | |
| chr16:1,770,847–1,771,973 | 55.2 kb | Distal (>10kb) Multiome | 485 | |
| chr16:1,772,565–1,774,049 | 53.4 kb | Distal (>10kb) Multiome | 956 | |
| chr16:1,781,749–1,783,420 | 44.1 kb | Distal (>10kb) Multiome | 761 | |
| chr16:1,826,102–1,827,535 | 102 bp | At TSS Multiome | 1006 | |
| chr16:1,918,171–1,918,773 | 91.6 kb | Distal (>10kb) Multiome | 129 | |
| chr16:1,929,283–1,930,271 | 103.0 kb | Distal (>10kb) Multiome | 780 | |
| chr16:1,942,671–1,943,761 | 116.6 kb | Distal (>10kb) Multiome | 750 | |
| chr16:1,958,923–1,960,140 | 132.7 kb | Distal (>10kb) Multiome | 826 | |
| chr16:1,964,300–1,965,434 | 138.1 kb | Distal (>10kb) Multiome | 933 | |
| chr16:1,971,481–1,972,435 | 145.2 kb | Distal (>10kb) Multiome | 1010 | |
| chr16:1,979,111–1,980,324 | 152.6 kb | Distal (>10kb) Multiome | 296 | |
| chr16:1,983,450–1,984,851 | 157.1 kb | Distal (>10kb) Multiome | 917 | |
| chr16:1,989,307–1,993,568 | 165.6 kb | Distal (>10kb) Multiome | 706 | |
| chr16:2,003,882–2,004,348 | 177.2 kb | Distal (>10kb) Multiome | 619 | |
| chr16:2,009,742–2,010,504 | 183.1 kb | Distal (>10kb) Multiome | 752 | |
| chr16:2,022,700–2,023,923 | 196.5 kb | Distal (>10kb) Multiome | 682 | |
| chr16:2,026,629–2,027,149 | 200.1 kb | Distal (>10kb) Multiome | 249 | |
| chr16:2,047,366–2,048,252 | 221.1 kb | Distal (>10kb) Multiome | 875 | |
| chr16:2,090,476–2,092,232 | 264.5 kb | Distal (>10kb) Multiome | 344 |
Genomic view of the HAGH locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.