The protein encoded by this gene contains a characteristic catalytic motif of the protein tyrosine phosphatases (PTPs) family. The PTP motif of this protein has the highly conserved arginine residue replaced by a proline residue; thus it may represent a distinct class of PTPs. Members of the PTP family are known to be signaling molecules that regulate a variety of cellular processes. This gene was preferentially expressed in both adult and fetal heart. A much lower expression level was detected in skeletal and smooth muscle tissues, and no expression was observed in other tissues. The tissue specific expression in the developing and adult heart suggests a role in regulating cardiac development and differentiation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for HACD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HACD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HACD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:17,379,036–17,380,059 | 237.9 kb | Distal (>10kb) Multiome | 120 | |
| chr10:17,387,758–17,388,950 | 229.1 kb | Distal (>10kb) Multiome | 319 | |
| chr10:17,453,122–17,455,034 | 163.0 kb | Distal (>10kb) Multiome | 584 | |
| chr10:17,607,603–17,607,786 | 9.6 kb | Proximal (<10kb) | 154 | |
| chr10:17,616,423–17,618,050 | 14 bp | At TSS Multiome | 800 | |
| chr10:17,643,443–17,644,922 | 26.7 kb | Distal (>10kb) Multiome | 877 | |
| chr10:17,673,416–17,674,078 | 56.4 kb | Distal (>10kb) Multiome | 368 | |
| chr10:17,836,569–17,837,890 | 219.8 kb | Distal (>10kb) Multiome | 195 | |
| chr10:17,907,502–17,908,396 | 290.6 kb | Distal (>10kb) Multiome | 133 |
Genomic view of the HACD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.