H3C8
H3 clustered histone 8 | H3/h, H3FH, HIST1H3G

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

Member of: DE-6 DE-6.13
Biological processes 31 terms
DNA binding (GO:0003677)cadherin binding (GO:0045296)chromatin organization (GO:0006325)chromosome (GO:0005694)epigenetic regulation of gene expression (GO:0040029)extracellular exosome (GO:0070062)extracellular exosome (GO:0070062)extracellular region (GO:0005576)heterochromatin formation (GO:0031507)membrane (GO:0016020)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleosomal DNA binding (GO:0031492)nucleosome (GO:0000786)nucleosome (GO:0000786)nucleosome (GO:0000786)nucleosome assembly (GO:0006334)nucleosome assembly (GO:0006334)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)protein-containing complex (GO:0032991)structural constituent of chromatin (GO:0030527)structural constituent of chromatin (GO:0030527)structural constituent of chromatin (GO:0030527)telomere organization (GO:0032200)
Expression (TPM)
H3C8 — as a Regulated Gene

TFs regulating H3C8 0 TFs

Transcription factors with Perturb-seq knockdown data for H3C8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = H3C8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to H3C8

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of H3C8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr6:25,992,391–25,993,479 278.7 kb Distal (>10kb) Multiome 1012
chr6:26,020,104–26,022,401 251.0 kb Distal (>10kb) Multiome 920
chr6:26,025,866–26,027,859 245.0 kb Distal (>10kb) Multiome 1194
chr6:26,031,341–26,032,990 239.2 kb Distal (>10kb) Multiome 1083
chr6:26,033,113–26,034,309 237.7 kb Distal (>10kb) Multiome 800
chr6:26,054,926–26,057,287 214.9 kb Distal (>10kb) Multiome 1174
chr6:26,087,383–26,088,017 183.7 kb Distal (>10kb) Multiome 572
chr6:26,103,452–26,105,109 167.5 kb Distal (>10kb) Multiome 1169
chr6:26,122,481–26,124,909 148.5 kb Distal (>10kb) Multiome 1216
chr6:26,156,184–26,158,744 113.4 kb Distal (>10kb) Multiome 1310
chr6:26,171,798–26,172,499 99.4 kb Distal (>10kb) Multiome 580
chr6:26,183,128–26,184,377 87.8 kb Distal (>10kb) Multiome 311
chr6:26,187,874–26,189,538 82.3 kb Distal (>10kb) Multiome 1053
chr6:26,196,695–26,197,676 74.2 kb Distal (>10kb) Multiome 842
chr6:26,198,203–26,200,197 72.0 kb Distal (>10kb) Multiome 939
chr6:26,203,791–26,205,119 66.9 kb Distal (>10kb) Multiome 1071
chr6:26,214,872–26,218,468 54.6 kb Distal (>10kb) Multiome 1096
chr6:26,223,716–26,224,480 47.4 kb Distal (>10kb) Multiome 507
chr6:26,224,856–26,226,566 46.2 kb Distal (>10kb) Multiome 451
chr6:26,239,944–26,240,920 31.1 kb Distal (>10kb) Multiome 375
chr6:26,249,682–26,251,138 21.1 kb Distal (>10kb) Multiome 731
chr6:26,251,339–26,252,079 19.7 kb Distal (>10kb) Multiome 445
chr6:26,268,981–26,269,368 2.0 kb Proximal (<10kb) 177
chr6:26,270,815–26,273,967 1.5 kb Proximal (<10kb) Multiome 742
chr6:26,285,011–26,286,121 14.2 kb Distal (>10kb) Multiome 1121
chr6:26,304,972–26,305,585 34.0 kb Distal (>10kb) Multiome 586
chr6:26,312,505–26,313,475 41.6 kb Distal (>10kb) Multiome 896
chr6:26,322,092–26,323,232 51.2 kb Distal (>10kb) Multiome 811
chr6:26,327,476–26,328,318 56.7 kb Distal (>10kb) Multiome 716
chr6:26,341,545–26,342,139 70.4 kb Distal (>10kb) Multiome 716
chr6:26,365,073–26,365,647 93.9 kb Distal (>10kb) Multiome 587
chr6:26,382,957–26,383,951 111.8 kb Distal (>10kb) Multiome 448
chr6:26,421,258–26,421,866 150.0 kb Distal (>10kb) Multiome 473
chr6:26,457,390–26,458,395 186.5 kb Distal (>10kb) Multiome 525
chr6:26,473,842–26,474,357 202.7 kb Distal (>10kb) Multiome 487
chr6:26,520,324–26,522,398 250.6 kb Distal (>10kb) Multiome 1082
chr6:26,532,765–26,533,409 261.7 kb Distal (>10kb) Multiome 830
chr6:26,537,180–26,538,912 266.1 kb Distal (>10kb) Multiome 1114
chr6:26,550,296–26,550,971 279.3 kb Distal (>10kb) Multiome 695
chr6:26,553,165–26,553,642 282.2 kb Distal (>10kb) Multiome 561
chr6:26,556,432–26,557,038 285.1 kb Distal (>10kb) Multiome 676
chr6:27,889,436–27,895,972 1619.5 kb Distal (>10kb) Multiome HiCAR 1215

Genome Browser

Genomic view of the H3C8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr6:25,982,391 – 27,905,972
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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