Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GZF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GZF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GZF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:23,102,752–23,103,227 | 259.3 kb | Distal (>10kb) Multiome | 47 | |
| chr20:23,178,656–23,179,482 | 183.2 kb | Distal (>10kb) Multiome | 198 | |
| chr20:23,211,541–23,212,970 | 149.8 kb | Distal (>10kb) Multiome | 321 | |
| chr20:23,349,714–23,351,638 | 11.6 kb | Distal (>10kb) Multiome | 1037 | |
| chr20:23,355,682–23,356,065 | 6.1 kb | Proximal (<10kb) | 17 | |
| chr20:23,356,179–23,356,563 | 5.6 kb | Proximal (<10kb) | 95 | |
| chr20:23,357,172–23,358,689 | 3.9 kb | Proximal (<10kb) Multiome | 873 | |
| chr20:23,361,395–23,363,116 | 139 bp | At TSS Multiome | 1092 | |
| chr20:23,420,902–23,421,923 | 59.4 kb | Distal (>10kb) Multiome | 823 | |
| chr20:23,637,267–23,638,378 | 275.8 kb | Distal (>10kb) Multiome | 884 |
Genomic view of the GZF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.