Predicted to enable GTP binding activity; GTPase activity; and metal ion binding activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GTPBP8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GTPBP8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GTPBP8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:112,785,378–112,786,966 | 204.7 kb | Distal (>10kb) Multiome | 290 | |
| chr3:112,990,506–112,991,646 | 98 bp | At TSS Multiome | 925 | |
| chr3:113,018,819–113,020,010 | 28.7 kb | Distal (>10kb) Multiome | 965 | |
| chr3:113,210,367–113,212,837 | 221.0 kb | Distal (>10kb) Multiome | 482 | |
| chr3:113,240,837–113,244,224 | 250.8 kb | Distal (>10kb) Multiome | 545 |
Genomic view of the GTPBP8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.