Enables RNA polymerase III general transcription initiation factor activity. Predicted to be involved in 5S class rRNA transcription by RNA polymerase III and tRNA transcription by RNA polymerase III. Predicted to act upstream of or within skeletal muscle cell differentiation. Located in nucleoplasm. Part of transcription factor TFIIIC complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GTF3C5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GTF3C5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GTF3C5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:132,770,159–132,770,672 | 260.5 kb | Distal (>10kb) Multiome | 385 | |
| chr9:132,794,730–132,795,358 | 236.0 kb | Distal (>10kb) Multiome | 159 | |
| chr9:132,877,859–132,878,978 | 152.6 kb | Distal (>10kb) Multiome | 676 | |
| chr9:132,944,084–132,945,377 | 86.2 kb | Distal (>10kb) Multiome | 983 | |
| chr9:133,022,373–133,022,665 | 8.0 kb | Proximal (<10kb) | 624 | |
| chr9:133,030,039–133,031,100 | 331 bp | At TSS Multiome | 998 | |
| chr9:133,059,688–133,060,833 | 29.5 kb | Distal (>10kb) Multiome HiCAR | 222 | |
| chr9:133,120,589–133,121,652 | 90.3 kb | Distal (>10kb) Multiome | 599 | |
| chr9:133,144,161–133,144,920 | 113.6 kb | Distal (>10kb) Multiome HiCAR | 776 | |
| chr9:133,147,412–133,149,938 | 118.4 kb | Distal (>10kb) Multiome HiCAR | 979 | |
| chr9:133,163,575–133,164,128 | 132.9 kb | Distal (>10kb) Multiome | 308 | |
| chr9:133,238,117–133,239,420 | 207.7 kb | Distal (>10kb) Multiome | 620 |
Genomic view of the GTF3C5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.