The protein encoded by this gene is part of the TFIIIC2 complex, which binds to the promoters of small nuclear and cytoplasmic RNA genes in order to recruit RNA polymerase III. The TFIIIC2 complex is composed of six subunits. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for GTF3C3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GTF3C3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GTF3C3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:196,592,181–196,593,965 | 206.6 kb | Distal (>10kb) Multiome | 567 | |
| chr2:196,639,223–196,641,327 | 160.0 kb | Distal (>10kb) Multiome | 902 | |
| chr2:196,799,143–196,800,218 | 25 bp | At TSS Multiome | 1098 | |
| chr2:196,808,391–196,808,580 | 8.9 kb | Proximal (<10kb) | 27 | |
| chr2:196,925,547–196,927,652 | 127.2 kb | Distal (>10kb) Multiome | 896 | |
| chr2:197,005,378–197,006,095 | 206.0 kb | Distal (>10kb) Multiome | 220 |
Genomic view of the GTF3C3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.