This gene encodes a member of the TFB4 family. The encoded protein is a subunit of the core-TFIIH basal transcription factor and localizes to the nucleus. The encoded protein is involved in RNA transcription by RNA polymerase II and nucleotide excision repair and associates with the Cdk-activating kinase complex. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 14. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for GTF2H3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GTF2H3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GTF2H3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:123,363,804–123,365,980 | 268.7 kb | Distal (>10kb) Multiome | 1015 | |
| chr12:123,383,367–123,384,963 | 249.9 kb | Distal (>10kb) Multiome | 836 | |
| chr12:123,388,500–123,389,409 | 245.0 kb | Distal (>10kb) Multiome | 446 | |
| chr12:123,436,072–123,436,895 | 197.2 kb | Distal (>10kb) Multiome | 742 | |
| chr12:123,458,045–123,458,697 | 175.4 kb | Distal (>10kb) Multiome | 925 | |
| chr12:123,533,444–123,534,540 | 99.8 kb | Distal (>10kb) Multiome | 718 | |
| chr12:123,583,890–123,585,003 | 49.4 kb | Distal (>10kb) Multiome | 928 | |
| chr12:123,601,617–123,602,401 | 31.8 kb | Distal (>10kb) Multiome | 1076 | |
| chr12:123,633,273–123,633,970 | 66 bp | At TSS Multiome | 886 | |
| chr12:123,670,899–123,671,414 | 37.3 kb | Distal (>10kb) Multiome | 469 | |
| chr12:123,711,684–123,712,955 | 78.4 kb | Distal (>10kb) Multiome | 771 | |
| chr12:123,719,176–123,720,140 | 85.8 kb | Distal (>10kb) Multiome | 303 | |
| chr12:123,761,832–123,763,058 | 128.2 kb | Distal (>10kb) Multiome | 416 |
Genomic view of the GTF2H3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.