Enables RNA polymerase II general transcription initiation factor activity. Involved in G protein-coupled receptor internalization and transcription initiation at RNA polymerase II promoter. Located in nuclear speck. Part of core TFIIH complex portion of holo TFIIH complex and transcription factor TFIID complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GTF2H2C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GTF2H2C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GTF2H2C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:69,300,544–69,301,286 | 259.3 kb | Distal (>10kb) Multiome | 217 | |
| chr5:69,368,998–69,370,235 | 190.5 kb | Distal (>10kb) Multiome | 956 | |
| chr5:69,414,852–69,415,897 | 145.0 kb | Distal (>10kb) Multiome HiCAR | 714 | |
| chr5:69,492,169–69,494,057 | 67.5 kb | Distal (>10kb) Multiome | 821 | |
| chr5:69,499,604–69,500,518 | 60.1 kb | Distal (>10kb) Multiome | 300 |
Genomic view of the GTF2H2C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.