GTF2A1

general transcription factor IIA subunit 1 | TFIIA

Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010]

Member of: DE-5

Biological processes 25 terms

DNA binding (GO:0003677)RNA polymerase II core promoter sequence-specific DNA binding (GO:0000979)RNA polymerase II general transcription initiation factor activity (GO:0016251)RNA polymerase II general transcription initiation factor activity (GO:0016251)RNA polymerase II general transcription initiation factor binding (GO:0001091)RNA polymerase II preinitiation complex assembly (GO:0051123)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)TBP-class protein binding (GO:0017025)cytoplasm (GO:0005737)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription initiation by RNA polymerase II (GO:0060261)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)transcription by RNA polymerase II (GO:0006366)transcription by RNA polymerase II (GO:0006366)transcription factor TFIIA complex (GO:0005672)transcription factor TFIIA complex (GO:0005672)transcription factor TFIIA complex (GO:0005672)transcription factor TFIID complex (GO:0005669)transcription initiation at RNA polymerase II promoter (GO:0006367)transcription preinitiation complex (GO:0097550)

Expression (TPM)

TFs regulating GTF2A1 0 TFs

Transcription factors with Perturb-seq knockdown data for GTF2A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GTF2A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GTF2A1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GTF2A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:80,941,041–80,942,411	279.2 kb	Distal (>10kb) Multiome	702
chr14:80,954,799–80,956,015	265.9 kb	Distal (>10kb) Multiome	534
chr14:81,169,725–81,171,107	50.4 kb	Distal (>10kb) Multiome	780
chr14:81,211,188–81,211,703	9.2 kb	Proximal (<10kb)	16
chr14:81,211,913–81,212,116	8.8 kb	Proximal (<10kb)	62
chr14:81,219,039–81,221,949	169 bp	At TSS Multiome	1204
chr14:81,323,510–81,324,729	103.2 kb	Distal (>10kb) Multiome	380
chr14:81,385,875–81,386,791	165.5 kb	Distal (>10kb) Multiome	212
chr14:81,435,308–81,437,022	215.5 kb	Distal (>10kb) Multiome	802

Genome Browser

Genomic view of the GTF2A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.