GSTO2
glutathione S-transferase omega 2

The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]

Developmental clusters: GC3
Biological processes 21 terms
L-ascorbic acid metabolic process (GO:0019852)L-ascorbic acid metabolic process (GO:0019852)L-ascorbic acid metabolic process (GO:0019852)cellular oxidant detoxification (GO:0098869)cellular response to arsenic-containing substance (GO:0071243)cellular response to arsenic-containing substance (GO:0071243)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)extracellular exosome (GO:0070062)glutathione dehydrogenase (ascorbate) activity (GO:0045174)glutathione dehydrogenase (ascorbate) activity (GO:0045174)glutathione dehydrogenase (ascorbate) activity (GO:0045174)glutathione metabolic process (GO:0006749)glutathione transferase activity (GO:0004364)glutathione transferase activity (GO:0004364)identical protein binding (GO:0042802)methylarsonate reductase activity (GO:0050610)oxidoreductase activity (GO:0016491)protein binding (GO:0005515)xenobiotic metabolic process (GO:0006805)
Expression (TPM)
GSTO2 — as a Regulated Gene

TFs regulating GSTO2 0 TFs

Transcription factors with Perturb-seq knockdown data for GSTO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GSTO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to GSTO2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GSTO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr10:104,045,227–104,046,125 229.4 kb Distal (>10kb) Multiome HiCAR 116
chr10:104,057,535–104,058,241 217.0 kb Distal (>10kb) Multiome HiCAR 66
chr10:104,120,766–104,122,782 153.0 kb Distal (>10kb) Multiome 959
chr10:104,155,284–104,156,268 119.0 kb Distal (>10kb) Multiome 175
chr10:104,231,576–104,232,903 42.5 kb Distal (>10kb) Multiome 777
chr10:104,252,389–104,254,221 21.5 kb Distal (>10kb) Multiome 583
chr10:104,254,370–104,255,379 20.0 kb Distal (>10kb) Multiome 714
chr10:104,268,486–104,269,500 5.8 kb Proximal (<10kb) Multiome 569
chr10:104,274,546–104,275,629 52 bp At TSS Multiome 513
chr10:104,281,772–104,282,042 6.9 kb Proximal (<10kb) 49
chr10:104,291,224–104,291,975 16.7 kb Distal (>10kb) Multiome 512
chr10:104,305,412–104,306,052 30.8 kb Distal (>10kb) Multiome 394
chr10:104,328,024–104,329,489 53.9 kb Distal (>10kb) Multiome 537
chr10:104,331,220–104,332,050 56.7 kb Distal (>10kb) Multiome 374
chr10:104,337,560–104,339,351 63.5 kb Distal (>10kb) Multiome 762
chr10:104,353,170–104,354,177 78.8 kb Distal (>10kb) Multiome 470
chr10:104,473,780–104,474,540 199.1 kb Distal (>10kb) Multiome 58
chr10:104,496,707–104,497,286 222.2 kb Distal (>10kb) Multiome 14

Genome Browser

Genomic view of the GSTO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr10:104,035,227 – 104,507,286
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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