This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
Transcription factors with Perturb-seq knockdown data for GSTK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GSTK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GSTK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:143,041,996–143,043,331 | 220.6 kb | Distal (>10kb) Multiome | 258 | |
| chr7:143,263,111–143,264,043 | 49 bp | At TSS Multiome | 857 | |
| chr7:143,284,394–143,285,772 | 21.5 kb | Distal (>10kb) Multiome | 381 | |
| chr7:143,287,670–143,288,978 | 24.8 kb | Distal (>10kb) Multiome | 878 | |
| chr7:143,345,279–143,346,282 | 82.2 kb | Distal (>10kb) Multiome | 433 | |
| chr7:143,361,157–143,363,235 | 99.3 kb | Distal (>10kb) Multiome | 388 | |
| chr7:143,380,012–143,382,328 | 117.7 kb | Distal (>10kb) Multiome | 946 | |
| chr7:143,405,536–143,406,754 | 142.7 kb | Distal (>10kb) Multiome | 194 | |
| chr7:143,407,435–143,409,651 | 145.5 kb | Distal (>10kb) Multiome | 459 |
Genomic view of the GSTK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.