The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for GSK3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GSK3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GSK3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:120,003,939–120,004,667 | 90.2 kb | Distal (>10kb) Multiome | 170 | |
| chr3:120,093,362–120,093,496 | 169 bp | At TSS | 98 | |
| chr3:120,093,804–120,096,088 | 389 bp | At TSS Multiome | 1114 | |
| chr3:120,284,858–120,285,627 | 190.8 kb | Distal (>10kb) Multiome | 237 | |
| chr3:120,348,500–120,350,077 | 254.8 kb | Distal (>10kb) Multiome | 1003 |
Genomic view of the GSK3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.