GSDMD
gasdermin D | DF5L, FLJ12150, GSDMDC1

Gasdermin D is a member of the gasdermin family. Members of this family appear to play a role in regulation of epithelial proliferation. Gasdermin D has been suggested to act as a tumor suppressor. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]

Biological processes 63 terms
NLRP3 inflammasome complex (GO:0072559)NLRP3 inflammasome complex (GO:0072559)NLRP3 inflammasome complex (GO:0072559)canonical inflammasome complex (GO:0061702)cardiolipin binding (GO:1901612)cardiolipin binding (GO:1901612)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)defense response to Gram-negative bacterium (GO:0050829)defense response to Gram-negative bacterium (GO:0050829)defense response to Gram-positive bacterium (GO:0050830)defense response to Gram-positive bacterium (GO:0050830)defense response to bacterium (GO:0042742)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)ficolin-1-rich granule lumen (GO:1904813)membrane (GO:0016020)mitochondrial membrane (GO:0031966)mitochondrial membrane (GO:0031966)nucleoplasm (GO:0005654)nucleus (GO:0005634)phosphatidic acid binding (GO:0070300)phosphatidic acid binding (GO:0070300)phosphatidylinositol-4,5-bisphosphate binding (GO:0005546)phosphatidylinositol-4,5-bisphosphate binding (GO:0005546)phosphatidylinositol-4,5-bisphosphate binding (GO:0005546)phosphatidylinositol-4-phosphate binding (GO:0070273)phosphatidylinositol-4-phosphate binding (GO:0070273)phosphatidylinositol-4-phosphate binding (GO:0070273)phosphatidylserine binding (GO:0001786)phosphatidylserine binding (GO:0001786)phosphatidylserine binding (GO:0001786)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)pore complex assembly (GO:0046931)pore complex assembly (GO:0046931)positive regulation of inflammatory response (GO:0050729)positive regulation of inflammatory response (GO:0050729)positive regulation of interleukin-1 beta production (GO:0032731)positive regulation of interleukin-1 beta production (GO:0032731)positive regulation of interleukin-1 production (GO:0032732)positive regulation of interleukin-18 production (GO:0032741)protein binding (GO:0005515)protein homooligomerization (GO:0051260)protein homooligomerization (GO:0051260)protein homooligomerization (GO:0051260)protein secretion (GO:0009306)protein secretion (GO:0009306)pyroptotic cell death (GO:0141201)pyroptotic cell death (GO:0141201)pyroptotic inflammatory response (GO:0070269)pyroptotic inflammatory response (GO:0070269)pyroptotic inflammatory response (GO:0070269)pyroptotic inflammatory response (GO:0070269)specific granule lumen (GO:0035580)tertiary granule lumen (GO:1904724)transmembrane transport (GO:0055085)wide pore channel activity (GO:0022829)wide pore channel activity (GO:0022829)
Expression (TPM)
GSDMD — as a Regulated Gene

TFs regulating GSDMD 0 TFs

Transcription factors with Perturb-seq knockdown data for GSDMD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GSDMD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to GSDMD

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GSDMD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr8:143,266,869–143,267,949 291.0 kb Distal (>10kb) Multiome 733
chr8:143,290,813–143,291,709 267.0 kb Distal (>10kb) Multiome 909
chr8:143,334,216–143,335,267 223.5 kb Distal (>10kb) Multiome 688
chr8:143,368,147–143,369,893 189.6 kb Distal (>10kb) Multiome 698
chr8:143,407,212–143,408,612 150.3 kb Distal (>10kb) Multiome 447
chr8:143,428,968–143,431,754 127.4 kb Distal (>10kb) Multiome 743
chr8:143,540,714–143,542,061 16.8 kb Distal (>10kb) Multiome 849
chr8:143,553,122–143,554,177 4.6 kb Proximal (<10kb) Multiome 775
chr8:143,558,225–143,558,936 170 bp At TSS Multiome 600
chr8:143,567,166–143,570,227 10.8 kb Distal (>10kb) Multiome 485
chr8:143,571,367–143,572,283 13.4 kb Distal (>10kb) Multiome 443
chr8:143,577,641–143,578,799 20.0 kb Distal (>10kb) Multiome 470
chr8:143,596,744–143,599,643 39.3 kb Distal (>10kb) Multiome 973
chr8:143,608,979–143,610,357 51.4 kb Distal (>10kb) Multiome 735
chr8:143,617,068–143,618,380 59.3 kb Distal (>10kb) Multiome 823
chr8:143,635,715–143,636,601 77.6 kb Distal (>10kb) Multiome 786
chr8:143,684,308–143,684,747 126.1 kb Distal (>10kb) Multiome 686
chr8:143,716,075–143,716,913 158.0 kb Distal (>10kb) Multiome 311
chr8:143,733,345–143,734,440 175.5 kb Distal (>10kb) Multiome 663
chr8:143,740,039–143,740,754 182.2 kb Distal (>10kb) Multiome 308
chr8:143,771,202–143,772,221 213.4 kb Distal (>10kb) Multiome 405
chr8:143,814,945–143,816,493 257.4 kb Distal (>10kb) Multiome 893
chr8:143,828,724–143,829,946 271.0 kb Distal (>10kb) Multiome 933
chr8:143,840,284–143,841,979 282.8 kb Distal (>10kb) Multiome 551

Genome Browser

Genomic view of the GSDMD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr8:143,256,869 – 143,851,979
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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