GSDMB

gasdermin B | PRO2521, GSDML

This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Alternative splicing and the use of alternative promoters results in multiple transcript variants. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. [provided by RefSeq, Nov 2016]

Developmental clusters: GC2

Biological processes 19 terms

cardiolipin binding (GO:1901612)cytoplasm (GO:0005737)cytosol (GO:0005829)cytotoxic T cell pyroptotic cell death (GO:1902483)defense response to Gram-negative bacterium (GO:0050829)defense response to bacterium (GO:0042742)granzyme-mediated programmed cell death signaling pathway (GO:0140507)natural killer cell mediated cytotoxicity (GO:0042267)phosphatidylinositol-4,5-bisphosphate binding (GO:0005546)phosphatidylinositol-4-phosphate binding (GO:0070273)phosphatidylserine binding (GO:0001786)phospholipid binding (GO:0005543)plasma membrane (GO:0005886)plasma membrane (GO:0005886)pyroptotic inflammatory response (GO:0070269)pyroptotic inflammatory response (GO:0070269)pyroptotic inflammatory response (GO:0070269)transmembrane transport (GO:0055085)wide pore channel activity (GO:0022829)

Expression (TPM)

TFs regulating GSDMB 0 TFs

Transcription factors with Perturb-seq knockdown data for GSDMB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GSDMB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GSDMB

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GSDMB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:39,636,769–39,637,600	280.2 kb	Distal (>10kb) Multiome	853
chr17:39,652,588–39,653,348	264.3 kb	Distal (>10kb) Multiome	263
chr17:39,668,234–39,668,690	248.8 kb	Distal (>10kb) Multiome	706
chr17:39,687,710–39,688,437	229.3 kb	Distal (>10kb) Multiome	800
chr17:39,695,905–39,696,636	221.0 kb	Distal (>10kb) Multiome	499
chr17:39,699,516–39,700,527	217.4 kb	Distal (>10kb) Multiome	528
chr17:39,730,039–39,730,906	186.8 kb	Distal (>10kb) Multiome	886
chr17:39,739,067–39,739,915	177.8 kb	Distal (>10kb) Multiome	648
chr17:39,740,384–39,740,910	176.6 kb	Distal (>10kb) Multiome	513
chr17:39,753,811–39,754,996	162.9 kb	Distal (>10kb) Multiome	1000
chr17:39,926,716–39,928,343	10.4 kb	Distal (>10kb) Multiome	942
chr17:39,952,356–39,953,923	35.8 kb	Distal (>10kb) Multiome	598
chr17:39,979,964–39,981,234	63.3 kb	Distal (>10kb) Multiome	1148
chr17:40,054,311–40,054,810	137.2 kb	Distal (>10kb) Multiome	694
chr17:40,062,700–40,063,624	145.7 kb	Distal (>10kb) Multiome	609
chr17:40,075,390–40,075,997	158.3 kb	Distal (>10kb) Multiome	556
chr17:40,098,950–40,099,858	181.9 kb	Distal (>10kb) Multiome	997
chr17:40,100,155–40,101,301	183.4 kb	Distal (>10kb) Multiome	954
chr17:40,111,702–40,112,164	194.5 kb	Distal (>10kb) Multiome	678
chr17:40,113,185–40,113,691	196.1 kb	Distal (>10kb) Multiome	864
chr17:40,121,452–40,123,602	204.6 kb	Distal (>10kb) Multiome	799
chr17:40,139,909–40,141,108	223.0 kb	Distal (>10kb) Multiome	1121
chr17:40,177,152–40,178,398	260.2 kb	Distal (>10kb) Multiome	329
chr17:40,191,326–40,192,022	274.5 kb	Distal (>10kb) Multiome	588
chr17:41,864,608–41,865,695	1948.1 kb	Distal (>10kb) Multiome HiCAR	913

Genome Browser

Genomic view of the GSDMB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.