GRPEL1

GrpE like 1, mitochondrial | FLJ25609, GrpE, hMGE

Enables identical protein binding activity and unfolded protein binding activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrial matrix and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1

Biological processes 19 terms

PAM complex, Tim23 associated import motor (GO:0001405)adenyl-nucleotide exchange factor activity (GO:0000774)adenyl-nucleotide exchange factor activity (GO:0000774)identical protein binding (GO:0042802)identical protein binding (GO:0042802)intracellular protein transport (GO:0006886)mitochondrial inner membrane (GO:0005743)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrion (GO:0005739)mitochondrion (GO:0005739)protein binding (GO:0005515)protein folding (GO:0006457)protein homodimerization activity (GO:0042803)protein import into mitochondrial matrix (GO:0030150)protein-folding chaperone binding (GO:0051087)unfolded protein binding (GO:0051082)unfolded protein binding (GO:0051082)

Expression (TPM)

TFs regulating GRPEL1 0 TFs

Transcription factors with Perturb-seq knockdown data for GRPEL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRPEL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GRPEL1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRPEL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr4:6,709,388–6,710,099	358.2 kb	Distal (>10kb) Multiome HiCAR	693
chr4:6,715,775–6,716,910	351.9 kb	Distal (>10kb) Multiome HiCAR	822
chr4:6,782,106–6,784,027	285.5 kb	Distal (>10kb) Multiome	886
chr4:6,908,950–6,910,715	158.5 kb	Distal (>10kb) Multiome HiCAR	820
chr4:6,986,472–6,987,825	80.9 kb	Distal (>10kb) Multiome	762
chr4:7,007,023–7,007,815	60.7 kb	Distal (>10kb) Multiome	59
chr4:7,042,101–7,044,552	24.9 kb	Distal (>10kb) Multiome	741
chr4:7,067,444–7,068,837	138 bp	At TSS Multiome	887
chr4:7,068,957–7,069,227	872 bp	At TSS	138
chr4:7,070,781–7,071,083	2.7 kb	Proximal (<10kb)	369
chr4:7,101,878–7,102,488	34.0 kb	Distal (>10kb) Multiome	437
chr4:7,102,990–7,103,713	35.4 kb	Distal (>10kb) Multiome	565
chr4:7,192,144–7,193,135	124.4 kb	Distal (>10kb) Multiome	236

Genome Browser

Genomic view of the GRPEL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.