This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GRK5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRK5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRK5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:119,022,769–119,023,594 | 184.4 kb | Distal (>10kb) Multiome | 196 | |
| chr10:119,028,784–119,030,985 | 178.1 kb | Distal (>10kb) Multiome | 776 | |
| chr10:119,080,039–119,081,458 | 126.7 kb | Distal (>10kb) Multiome | 953 | |
| chr10:119,092,145–119,092,653 | 115.1 kb | Distal (>10kb) Multiome | 103 | |
| chr10:119,103,400–119,104,998 | 103.5 kb | Distal (>10kb) Multiome | 607 | |
| chr10:119,140,467–119,141,205 | 66.6 kb | Distal (>10kb) Multiome | 164 | |
| chr10:119,165,095–119,166,223 | 41.9 kb | Distal (>10kb) Multiome | 815 | |
| chr10:119,178,426–119,179,231 | 28.8 kb | Distal (>10kb) Multiome | 801 | |
| chr10:119,199,474–119,199,686 | 7.9 kb | Proximal (<10kb) | 254 | |
| chr10:119,206,342–119,208,274 | 208 bp | At TSS Multiome | 780 | |
| chr10:119,209,556–119,209,769 | 2.0 kb | Proximal (<10kb) | 266 |
Genomic view of the GRK5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.