GRIN3B

glutamate ionotropic receptor NMDA type subunit 3B | GluN3B

The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia. [provided by RefSeq, Nov 2015]

Biological processes 44 terms

NMDA glutamate receptor activity (GO:0004972)NMDA selective glutamate receptor complex (GO:0017146)NMDA selective glutamate receptor complex (GO:0017146)NMDA selective glutamate receptor complex (GO:0017146)calcium channel activity (GO:0005262)calcium channel activity (GO:0005262)calcium ion transmembrane transport (GO:0070588)glutamate receptor activity (GO:0008066)glycine binding (GO:0016594)glycine-gated cation channel activity (GO:0160212)ionotropic glutamate receptor signaling pathway (GO:0035235)ionotropic glutamate receptor signaling pathway (GO:0035235)ligand-gated monoatomic ion channel activity (GO:0015276)ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507)ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507)ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507)membrane (GO:0016020)modulation of chemical synaptic transmission (GO:0050804)monoatomic cation channel activity (GO:0005261)monoatomic cation transmembrane transport (GO:0098655)monoatomic ion channel activity (GO:0005216)monoatomic ion transport (GO:0006811)neuronal cell body (GO:0043025)neuronal cell body (GO:0043025)neurotransmitter receptor activity (GO:0030594)neurotransmitter receptor complex (GO:0098878)neurotransmitter receptor complex (GO:0098878)plasma membrane (GO:0005886)plasma membrane (GO:0005886)postsynaptic density membrane (GO:0098839)postsynaptic membrane (GO:0045211)presynaptic membrane (GO:0042734)protein insertion into membrane (GO:0051205)protein insertion into membrane (GO:0051205)regulation of calcium ion transport (GO:0051924)regulation of calcium ion transport (GO:0051924)regulation of postsynaptic membrane potential (GO:0060078)regulation of presynaptic membrane potential (GO:0099505)regulation of synaptic plasticity (GO:0048167)regulation of synaptic plasticity (GO:0048167)signaling receptor activity (GO:0038023)synaptic transmission, glutamatergic (GO:0035249)transmitter-gated monoatomic ion channel activity (GO:0022824)transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315)

Expression (TPM)

TFs regulating GRIN3B 0 TFs

Transcription factors with Perturb-seq knockdown data for GRIN3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRIN3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GRIN3B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRIN3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:703,387–704,718	296.4 kb	Distal (>10kb) Multiome	586
chr19:708,425–709,293	291.6 kb	Distal (>10kb) Multiome	317
chr19:796,668–798,362	203.2 kb	Distal (>10kb) Multiome	956
chr19:821,294–822,728	178.3 kb	Distal (>10kb) Multiome	254
chr19:861,664–863,223	138.2 kb	Distal (>10kb) Multiome	530
chr19:892,703–893,746	107.2 kb	Distal (>10kb) Multiome	715
chr19:917,038–918,169	82.6 kb	Distal (>10kb) Multiome	711
chr19:924,743–926,242	74.7 kb	Distal (>10kb) Multiome	796
chr19:927,058–927,629	73.1 kb	Distal (>10kb) Multiome	362
chr19:982,565–983,215	17.6 kb	Distal (>10kb) Multiome	590
chr19:984,046–985,154	15.9 kb	Distal (>10kb) Multiome	829
chr19:991,298–991,443	9.0 kb	Proximal (<10kb)	100
chr19:991,838–992,214	8.2 kb	Proximal (<10kb)	186
chr19:1,000,142–1,000,881	78 bp	At TSS Multiome	399
chr19:1,001,581–1,001,945	1.2 kb	Proximal (<10kb)	375
chr19:1,020,611–1,022,069	21.0 kb	Distal (>10kb) Multiome	1017
chr19:1,026,155–1,026,856	26.1 kb	Distal (>10kb) Multiome	598
chr19:1,027,770–1,028,926	28.1 kb	Distal (>10kb) Multiome	584
chr19:1,039,648–1,040,400	39.6 kb	Distal (>10kb) Multiome	684
chr19:1,040,481–1,041,402	40.8 kb	Distal (>10kb) Multiome	556
chr19:1,061,840–1,062,923	62.1 kb	Distal (>10kb) Multiome	204
chr19:1,063,045–1,065,722	64.4 kb	Distal (>10kb) Multiome	681
chr19:1,066,682–1,067,587	66.8 kb	Distal (>10kb) Multiome	489
chr19:1,081,317–1,083,172	82.0 kb	Distal (>10kb) Multiome	484
chr19:1,094,985–1,095,654	95.0 kb	Distal (>10kb) Multiome	671
chr19:1,103,487–1,105,654	103.6 kb	Distal (>10kb) Multiome	849
chr19:1,112,029–1,112,884	111.9 kb	Distal (>10kb) Multiome	294
chr19:1,113,014–1,114,139	113.1 kb	Distal (>10kb) Multiome	690
chr19:1,173,441–1,174,438	173.8 kb	Distal (>10kb) Multiome	682
chr19:1,194,370–1,194,985	194.2 kb	Distal (>10kb) Multiome	531
chr19:1,205,175–1,206,374	205.2 kb	Distal (>10kb) Multiome HiCAR	746
chr19:1,237,080–1,238,434	237.7 kb	Distal (>10kb) Multiome	430
chr19:1,239,513–1,242,539	241.3 kb	Distal (>10kb) Multiome	889
chr19:1,244,253–1,244,857	244.2 kb	Distal (>10kb) Multiome	590
chr19:1,247,981–1,252,501	250.6 kb	Distal (>10kb) Multiome	1136
chr19:1,259,185–1,262,955	259.0 kb	Distal (>10kb) Multiome	1070
chr19:1,265,280–1,270,235	268.9 kb	Distal (>10kb) Multiome	1171
chr19:1,274,423–1,276,502	275.3 kb	Distal (>10kb) Multiome	967
chr19:1,285,317–1,286,108	285.4 kb	Distal (>10kb) Multiome	277

Genome Browser

Genomic view of the GRIN3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.