GRIN2D
glutamate ionotropic receptor NMDA type subunit 2D | EB11, GluN2D, NR2D, NMDAR2D

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010]

Developmental clusters: GC3
Biological processes 66 terms
NMDA glutamate receptor activity (GO:0004972)NMDA glutamate receptor activity (GO:0004972)NMDA glutamate receptor activity (GO:0004972)NMDA glutamate receptor activity (GO:0004972)NMDA glutamate receptor activity (GO:0004972)NMDA selective glutamate receptor complex (GO:0017146)NMDA selective glutamate receptor complex (GO:0017146)NMDA selective glutamate receptor complex (GO:0017146)NMDA selective glutamate receptor complex (GO:0017146)brain development (GO:0007420)calcium ion transmembrane import into cytosol (GO:0097553)calcium ion transmembrane import into cytosol (GO:0097553)calcium-mediated signaling (GO:0019722)cellular response to L-glutamate (GO:1905232)endoplasmic reticulum membrane (GO:0005789)excitatory chemical synaptic transmission (GO:0098976)excitatory postsynaptic potential (GO:0060079)glutamate binding (GO:0016595)glutamate-gated calcium ion channel activity (GO:0022849)glutamate-gated receptor activity (GO:0004970)glutamate-gated receptor activity (GO:0004970)glutamatergic synapse (GO:0098978)hippocampal mossy fiber to CA3 synapse (GO:0098686)ionotropic glutamate receptor signaling pathway (GO:0035235)ionotropic glutamate receptor signaling pathway (GO:0035235)ligand-gated monoatomic ion channel activity (GO:0015276)ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential (GO:0099507)long-term synaptic potentiation (GO:0060291)membrane (GO:0016020)monoatomic cation channel activity (GO:0005261)monoatomic cation transmembrane transport (GO:0098655)monoatomic cation transmembrane transport (GO:0098655)monoatomic cation transmembrane transport (GO:0098655)monoatomic ion channel activity (GO:0005216)monoatomic ion transport (GO:0006811)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of excitatory postsynaptic potential (GO:2000463)positive regulation of excitatory postsynaptic potential (GO:2000463)positive regulation of synaptic transmission, glutamatergic (GO:0051968)positive regulation of synaptic transmission, glutamatergic (GO:0051968)postsynaptic density membrane (GO:0098839)postsynaptic density membrane (GO:0098839)postsynaptic membrane (GO:0045211)postsynaptic membrane (GO:0045211)postsynaptic membrane (GO:0045211)presynaptic active zone membrane (GO:0048787)presynaptic membrane (GO:0042734)protein binding (GO:0005515)regulation of monoatomic cation transmembrane transport (GO:1904062)regulation of monoatomic cation transmembrane transport (GO:1904062)regulation of neuronal synaptic plasticity (GO:0048168)regulation of presynaptic membrane potential (GO:0099505)regulation of synaptic plasticity (GO:0048167)regulation of synaptic plasticity (GO:0048167)regulation of synaptic plasticity (GO:0048167)signaling receptor activity (GO:0038023)synapse (GO:0045202)synaptic transmission, glutamatergic (GO:0035249)synaptic transmission, glutamatergic (GO:0035249)transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315)transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315)voltage-gated monoatomic cation channel activity (GO:0022843)
Expression (TPM)
GRIN2D — as a Regulated Gene

TFs regulating GRIN2D 0 TFs

Transcription factors with Perturb-seq knockdown data for GRIN2D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRIN2D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to GRIN2D

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRIN2D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:48,169,480–48,171,282 223.2 kb Distal (>10kb) Multiome 950
chr19:48,203,709–48,204,551 189.6 kb Distal (>10kb) Multiome 741
chr19:48,271,198–48,272,050 122.1 kb Distal (>10kb) Multiome 562
chr19:48,290,181–48,291,716 102.8 kb Distal (>10kb) Multiome 666
chr19:48,320,062–48,322,328 72.2 kb Distal (>10kb) Multiome 826
chr19:48,330,094–48,330,787 63.4 kb Distal (>10kb) Multiome 460
chr19:48,332,701–48,333,506 60.8 kb Distal (>10kb) Multiome 615
chr19:48,333,584–48,334,372 59.6 kb Distal (>10kb) Multiome 554
chr19:48,363,062–48,364,710 29.5 kb Distal (>10kb) Multiome 940
chr19:48,390,663–48,391,935 2.1 kb Proximal (<10kb) Multiome 816
chr19:48,393,636–48,394,171 at TSS At TSS 255
chr19:48,397,916–48,399,301 5.2 kb Proximal (<10kb) Multiome 619
chr19:48,399,411–48,400,900 6.9 kb Proximal (<10kb) Multiome 548
chr19:48,414,121–48,416,085 21.9 kb Distal (>10kb) Multiome 298
chr19:48,445,379–48,446,456 52.2 kb Distal (>10kb) Multiome 845
chr19:48,468,758–48,470,027 75.5 kb Distal (>10kb) Multiome 860
chr19:48,490,661–48,494,449 97.7 kb Distal (>10kb) Multiome 633
chr19:48,500,898–48,503,050 108.4 kb Distal (>10kb) Multiome 656
chr19:48,510,624–48,511,212 117.1 kb Distal (>10kb) Multiome 268
chr19:48,513,480–48,514,294 120.2 kb Distal (>10kb) Multiome 585
chr19:48,614,318–48,615,255 221.2 kb Distal (>10kb) Multiome 524
chr19:48,618,726–48,619,869 225.7 kb Distal (>10kb) Multiome 1012
chr19:48,623,839–48,624,688 230.6 kb Distal (>10kb) Multiome 529
chr19:48,629,369–48,631,306 236.4 kb Distal (>10kb) Multiome 402
chr19:48,634,242–48,636,244 242.0 kb Distal (>10kb) Multiome 868
chr19:48,636,802–48,639,603 244.7 kb Distal (>10kb) Multiome 956
chr19:48,645,454–48,647,163 252.9 kb Distal (>10kb) Multiome 750
chr19:48,675,421–48,675,873 281.9 kb Distal (>10kb) Multiome 415

Genome Browser

Genomic view of the GRIN2D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:48,159,480 – 48,685,873
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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