This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GRHPR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRHPR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRHPR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:37,415,054–37,415,560 | 7.4 kb | Proximal (<10kb) Multiome | 414 | |
| chr9:37,422,138–37,423,121 | 54 bp | At TSS Multiome | 814 | |
| chr9:37,464,634–37,466,782 | 42.8 kb | Distal (>10kb) Multiome | 997 | |
| chr9:37,485,291–37,486,541 | 63.2 kb | Distal (>10kb) Multiome | 734 | |
| chr9:37,575,608–37,576,724 | 153.6 kb | Distal (>10kb) Multiome | 608 | |
| chr9:37,592,006–37,592,956 | 169.9 kb | Distal (>10kb) Multiome | 990 | |
| chr9:37,650,357–37,651,703 | 228.2 kb | Distal (>10kb) Multiome | 403 |
Genomic view of the GRHPR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.