Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in cellular response to cholesterol and intracellular sterol transport. Predicted to be located in endoplasmic reticulum; membrane; and organelle membrane contact site. Predicted to be active in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GRAMD1C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRAMD1C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRAMD1C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:113,695,756–113,697,740 | 142.1 kb | Distal (>10kb) Multiome | 796 | |
| chr3:113,744,989–113,747,921 | 91.9 kb | Distal (>10kb) Multiome | 1061 | |
| chr3:113,833,346–113,833,724 | 5.1 kb | Proximal (<10kb) | 8 | |
| chr3:113,838,330–113,839,358 | 16 bp | At TSS Multiome | 588 | |
| chr3:113,947,254–113,948,963 | 109.3 kb | Distal (>10kb) Multiome | 685 | |
| chr3:114,056,072–114,057,305 | 217.8 kb | Distal (>10kb) Multiome | 831 |
Genomic view of the GRAMD1C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.