Predicted to enable cholesterol binding activity and cholesterol transfer activity. Predicted to be involved in cellular response to cholesterol and intracellular sterol transport. Located in several cellular components, including cytosol; endoplasmic reticulum membrane; and organelle membrane contact site. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GRAMD1A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GRAMD1A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GRAMD1A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:34,733,416–34,734,655 | 266.1 kb | Distal (>10kb) Multiome | 1008 | |
| chr19:34,772,709–34,773,413 | 227.1 kb | Distal (>10kb) Multiome | 680 | |
| chr19:34,920,040–34,921,057 | 79.8 kb | Distal (>10kb) Multiome | 309 | |
| chr19:34,926,731–34,927,343 | 73.3 kb | Distal (>10kb) Multiome | 741 | |
| chr19:34,963,909–34,964,414 | 36.1 kb | Distal (>10kb) Multiome | 645 | |
| chr19:34,999,304–35,000,970 | 112 bp | At TSS Multiome | 759 | |
| chr19:35,003,286–35,003,640 | 3.0 kb | Proximal (<10kb) | 379 | |
| chr19:35,030,124–35,031,270 | 30.2 kb | Distal (>10kb) Multiome | 534 | |
| chr19:35,040,969–35,041,953 | 41.3 kb | Distal (>10kb) Multiome | 806 | |
| chr19:35,055,754–35,056,570 | 55.7 kb | Distal (>10kb) Multiome | 268 | |
| chr19:35,066,952–35,067,448 | 66.9 kb | Distal (>10kb) Multiome | 497 | |
| chr19:35,067,923–35,068,779 | 68.4 kb | Distal (>10kb) Multiome | 190 | |
| chr19:35,090,562–35,091,150 | 90.5 kb | Distal (>10kb) Multiome | 303 | |
| chr19:35,135,242–35,135,695 | 135.2 kb | Distal (>10kb) Multiome | 525 | |
| chr19:35,140,763–35,141,948 | 141.0 kb | Distal (>10kb) Multiome | 509 | |
| chr19:35,142,085–35,143,541 | 142.7 kb | Distal (>10kb) Multiome | 328 | |
| chr19:35,154,641–35,155,298 | 154.8 kb | Distal (>10kb) Multiome | 552 | |
| chr19:35,247,580–35,249,688 | 248.4 kb | Distal (>10kb) Multiome | 1088 | |
| chr19:35,266,852–35,270,128 | 269.4 kb | Distal (>10kb) Multiome | 869 |
Genomic view of the GRAMD1A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.