G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Transcription factors with Perturb-seq knockdown data for GPSM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPSM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPSM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:136,051,068–136,051,829 | 276.0 kb | Distal (>10kb) Multiome | 353 | |
| chr9:136,094,901–136,095,992 | 232.0 kb | Distal (>10kb) Multiome | 445 | |
| chr9:136,109,321–136,110,010 | 217.8 kb | Distal (>10kb) Multiome | 643 | |
| chr9:136,117,952–136,119,826 | 208.6 kb | Distal (>10kb) Multiome | 931 | |
| chr9:136,132,442–136,133,645 | 194.3 kb | Distal (>10kb) Multiome | 343 | |
| chr9:136,245,219–136,246,310 | 81.6 kb | Distal (>10kb) Multiome | 608 | |
| chr9:136,267,002–136,267,928 | 60.1 kb | Distal (>10kb) Multiome | 459 | |
| chr9:136,327,140–136,327,919 | 115 bp | At TSS Multiome | 310 | |
| chr9:136,342,464–136,343,245 | 15.4 kb | Distal (>10kb) Multiome | 326 | |
| chr9:136,362,899–136,364,677 | 35.9 kb | Distal (>10kb) Multiome | 969 | |
| chr9:136,399,639–136,400,642 | 72.8 kb | Distal (>10kb) Multiome | 776 | |
| chr9:136,410,307–136,410,943 | 83.1 kb | Distal (>10kb) Multiome | 740 | |
| chr9:136,438,826–136,440,227 | 112.4 kb | Distal (>10kb) Multiome | 608 | |
| chr9:136,482,405–136,485,297 | 155.9 kb | Distal (>10kb) Multiome | 938 | |
| chr9:136,545,392–136,547,129 | 218.7 kb | Distal (>10kb) Multiome | 710 | |
| chr9:136,572,053–136,572,865 | 244.9 kb | Distal (>10kb) Multiome | 239 | |
| chr9:136,587,135–136,588,835 | 260.9 kb | Distal (>10kb) Multiome | 453 | |
| chr9:136,626,479–136,627,366 | 299.4 kb | Distal (>10kb) Multiome | 451 |
Genomic view of the GPSM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.