Transcription factors with Perturb-seq knockdown data for GPS2P2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPS2P2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPS2P2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:186,772,225–186,772,685 | at TSS | At TSS | 147 | |
| chr3:186,772,788–186,773,308 | 200 bp | At TSS | 241 | |
| chr3:186,775,941–186,776,679 | 3.4 kb | Proximal (<10kb) | 161 | |
| chr3:186,781,841–186,782,091 | 9.3 kb | Proximal (<10kb) | 30 |
Genomic view of the GPS2P2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.