Predicted to be involved in neuron projection development. Predicted to act upstream of or within several processes, including excitatory chemical synaptic transmission; neuronal action potential; and vitamin D receptor signaling pathway. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for GPRIN3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPRIN3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPRIN3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:89,056,706–89,057,525 | 250.8 kb | Distal (>10kb) Multiome | 504 | |
| chr4:89,110,600–89,112,226 | 196.5 kb | Distal (>10kb) Multiome | 989 | |
| chr4:89,226,645–89,227,470 | 80.9 kb | Distal (>10kb) Multiome | 313 | |
| chr4:89,307,277–89,308,558 | 47 bp | At TSS Multiome | 440 |
Genomic view of the GPRIN3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.