The protein encoded by this gene is a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The specific function of this protein is unknown; however, this protein may mediate the cellular effects of retinoic acid on the G protein signal transduction cascade. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GPRC5C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPRC5C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPRC5C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:74,203,138–74,204,108 | 228.5 kb | Distal (>10kb) Multiome | 1032 | |
| chr17:74,210,772–74,213,995 | 218.6 kb | Distal (>10kb) Multiome | 756 | |
| chr17:74,245,260–74,245,769 | 186.5 kb | Distal (>10kb) Multiome | 132 | |
| chr17:74,296,413–74,296,895 | 135.5 kb | Distal (>10kb) Multiome | 369 | |
| chr17:74,325,836–74,326,504 | 105.9 kb | Distal (>10kb) Multiome | 237 | |
| chr17:74,351,773–74,352,296 | 80.2 kb | Distal (>10kb) Multiome | 202 | |
| chr17:74,379,476–74,379,948 | 52.5 kb | Distal (>10kb) Multiome HiCAR | 522 | |
| chr17:74,414,550–74,415,075 | 17.3 kb | Distal (>10kb) Multiome | 72 | |
| chr17:74,430,543–74,431,166 | 965 bp | At TSS | 775 | |
| chr17:74,431,757–74,432,660 | 58 bp | At TSS Multiome | 791 | |
| chr17:74,453,513–74,454,652 | 22.0 kb | Distal (>10kb) Multiome | 751 | |
| chr17:74,642,311–74,642,966 | 210.8 kb | Distal (>10kb) Multiome | 119 | |
| chr17:74,643,823–74,644,224 | 212.1 kb | Distal (>10kb) Multiome | 17 | |
| chr17:74,671,047–74,671,700 | 239.3 kb | Distal (>10kb) Multiome | 938 |
Genomic view of the GPRC5C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.