Enables voltage-gated monoatomic anion channel activity. Involved in intracellular pH reduction. Located in Golgi cisterna membrane and Golgi-associated vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GPR89B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPR89B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPR89B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:147,669,496–147,671,101 | 257.9 kb | Distal (>10kb) Multiome | 793 | |
| chr1:147,820,658–147,821,597 | 107.3 kb | Distal (>10kb) Multiome | 92 | |
| chr1:147,833,206–147,834,500 | 94.3 kb | Distal (>10kb) Multiome | 152 | |
| chr1:147,928,204–147,928,767 | 12 bp | At TSS Multiome | 240 | |
| chr1:148,038,392–148,038,981 | 110.3 kb | Distal (>10kb) Multiome | 522 | |
| chr1:148,263,120–148,264,484 | 335.2 kb | Distal (>10kb) Multiome HiCAR | 872 |
Genomic view of the GPR89B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.