This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associated with a significant reduction in food intake and impaired decision making ability. Mutations in this gene are associated with schizophrenia, autism, and other neuropsychiatric disorders. The expression of this gene is activated by the glioma-associated oncogene homolog 1 transcription factor which, in turn, is activated by sonic hedgehog in normal and tumorigenic cells. [provided by RefSeq, Feb 2017]
Transcription factors with Perturb-seq knockdown data for GPR153. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPR153 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPR153, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:5,980,417–5,980,986 | 280.4 kb | Distal (>10kb) Multiome | 282 | |
| chr1:5,991,687–5,993,712 | 268.5 kb | Distal (>10kb) Multiome | 829 | |
| chr1:6,127,538–6,128,516 | 133.2 kb | Distal (>10kb) Multiome | 300 | |
| chr1:6,148,503–6,149,108 | 112.3 kb | Distal (>10kb) Multiome | 254 | |
| chr1:6,199,148–6,200,364 | 61.4 kb | Distal (>10kb) Multiome | 992 | |
| chr1:6,204,893–6,206,690 | 55.8 kb | Distal (>10kb) Multiome | 913 | |
| chr1:6,208,737–6,209,635 | 51.7 kb | Distal (>10kb) Multiome | 362 | |
| chr1:6,235,160–6,236,710 | 25.1 kb | Distal (>10kb) Multiome | 673 | |
| chr1:6,241,773–6,242,771 | 18.9 kb | Distal (>10kb) Multiome | 241 | |
| chr1:6,244,532–6,247,144 | 15.1 kb | Distal (>10kb) Multiome | 1073 | |
| chr1:6,248,779–6,250,153 | 11.6 kb | Distal (>10kb) Multiome | 287 | |
| chr1:6,259,688–6,261,954 | 927 bp | At TSS Multiome | 550 | |
| chr1:6,392,724–6,394,325 | 132.5 kb | Distal (>10kb) Multiome | 819 | |
| chr1:6,418,998–6,420,339 | 158.7 kb | Distal (>10kb) Multiome HiCAR | 335 | |
| chr1:6,440,165–6,441,114 | 179.5 kb | Distal (>10kb) Multiome | 215 | |
| chr1:6,446,981–6,449,427 | 186.0 kb | Distal (>10kb) Multiome | 665 | |
| chr1:6,455,053–6,455,773 | 194.2 kb | Distal (>10kb) Multiome | 105 | |
| chr1:6,470,716–6,471,189 | 209.8 kb | Distal (>10kb) Multiome | 148 | |
| chr1:6,471,308–6,471,972 | 210.5 kb | Distal (>10kb) Multiome | 192 | |
| chr1:6,486,194–6,486,953 | 225.5 kb | Distal (>10kb) Multiome | 416 | |
| chr1:6,489,772–6,491,050 | 229.0 kb | Distal (>10kb) Multiome | 676 | |
| chr1:6,497,162–6,497,841 | 236.4 kb | Distal (>10kb) Multiome | 324 | |
| chr1:6,554,053–6,554,774 | 293.4 kb | Distal (>10kb) Multiome | 897 |
Genomic view of the GPR153 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.