Predicted to enable clathrin heavy chain binding activity. Predicted to be involved in clathrin-dependent endocytosis. Located in Golgi apparatus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GPR107. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPR107 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPR107, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:129,802,988–129,803,555 | 250.7 kb | Distal (>10kb) Multiome | 727 | |
| chr9:129,835,192–129,835,687 | 218.5 kb | Distal (>10kb) Multiome | 701 | |
| chr9:130,042,478–130,043,723 | 10.6 kb | Distal (>10kb) Multiome | 793 | |
| chr9:130,053,816–130,054,191 | at TSS | At TSS | 784 | |
| chr9:130,171,788–130,172,513 | 118.4 kb | Distal (>10kb) Multiome | 253 | |
| chr9:130,214,219–130,214,715 | 160.6 kb | Distal (>10kb) Multiome | 146 | |
| chr9:130,243,058–130,243,650 | 189.4 kb | Distal (>10kb) Multiome | 380 | |
| chr9:130,265,477–130,266,015 | 211.8 kb | Distal (>10kb) Multiome | 214 |
Genomic view of the GPR107 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.