The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]
Transcription factors with Perturb-seq knockdown data for GPD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:156,319,450–156,320,925 | 116.2 kb | Distal (>10kb) Multiome | 436 | |
| chr2:156,328,946–156,330,425 | 107.0 kb | Distal (>10kb) Multiome | 234 | |
| chr2:156,331,954–156,335,284 | 103.6 kb | Distal (>10kb) Multiome | 953 | |
| chr2:156,341,183–156,343,169 | 93.8 kb | Distal (>10kb) Multiome | 912 | |
| chr2:156,399,513–156,401,541 | 35.6 kb | Distal (>10kb) Multiome | 1057 | |
| chr2:156,435,321–156,437,130 | 185 bp | At TSS Multiome | 723 | |
| chr2:156,630,698–156,631,385 | 194.7 kb | Distal (>10kb) Multiome | 154 |
Genomic view of the GPD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.