Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GPC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:240,135,834–240,136,678 | 299.3 kb | Distal (>10kb) Multiome | 753 | |
| chr2:240,232,596–240,234,436 | 202.2 kb | Distal (>10kb) Multiome HiCAR | 492 | |
| chr2:240,434,652–240,436,967 | 191 bp | At TSS Multiome | 516 | |
| chr2:240,438,139–240,438,545 | 2.5 kb | Proximal (<10kb) | 342 | |
| chr2:240,452,173–240,453,282 | 17.1 kb | Distal (>10kb) Multiome | 285 | |
| chr2:240,455,722–240,456,136 | 2.9 kb | Proximal (<10kb) | 143 | |
| chr2:240,557,164–240,558,401 | 122.4 kb | Distal (>10kb) Multiome | 226 | |
| chr2:240,560,183–240,561,566 | 124.7 kb | Distal (>10kb) Multiome | 1021 | |
| chr2:240,566,043–240,567,010 | 130.9 kb | Distal (>10kb) Multiome | 749 | |
| chr2:240,567,779–240,569,178 | 132.8 kb | Distal (>10kb) Multiome | 615 | |
| chr2:240,586,073–240,587,459 | 150.9 kb | Distal (>10kb) Multiome | 893 | |
| chr2:240,670,022–240,670,734 | 234.7 kb | Distal (>10kb) Multiome | 19 |
Genomic view of the GPC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.