The protein encoded by this gene contains an RNA-processing domain, a zinc finger domain, a lysine-rich region and a serine-rich region. A mutation in the serine-rich region of the protein is thought to be associated with hyperuricemia (PMID: 21594610). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
Transcription factors with Perturb-seq knockdown data for GPATCH8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPATCH8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPATCH8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:44,210,257–44,210,930 | 292.8 kb | Distal (>10kb) Multiome | 568 | |
| chr17:44,218,107–44,221,629 | 284.8 kb | Distal (>10kb) Multiome | 936 | |
| chr17:44,221,765–44,222,816 | 281.1 kb | Distal (>10kb) Multiome | 597 | |
| chr17:44,307,755–44,309,164 | 194.9 kb | Distal (>10kb) Multiome | 726 | |
| chr17:44,314,945–44,315,776 | 188.1 kb | Distal (>10kb) Multiome | 273 | |
| chr17:44,316,273–44,316,728 | 186.9 kb | Distal (>10kb) Multiome | 183 | |
| chr17:44,324,218–44,325,841 | 178.5 kb | Distal (>10kb) Multiome | 852 | |
| chr17:44,326,610–44,327,149 | 176.4 kb | Distal (>10kb) Multiome | 599 | |
| chr17:44,344,826–44,346,001 | 158.2 kb | Distal (>10kb) Multiome | 837 | |
| chr17:44,353,667–44,355,182 | 148.7 kb | Distal (>10kb) Multiome | 393 | |
| chr17:44,363,447–44,364,077 | 139.6 kb | Distal (>10kb) Multiome | 502 | |
| chr17:44,374,688–44,375,216 | 128.5 kb | Distal (>10kb) Multiome | 299 | |
| chr17:44,384,542–44,386,175 | 117.9 kb | Distal (>10kb) Multiome | 553 | |
| chr17:44,502,912–44,504,091 | 110 bp | At TSS Multiome | 999 | |
| chr17:44,511,786–44,512,174 | 8.4 kb | Proximal (<10kb) | 174 | |
| chr17:44,539,724–44,540,529 | 36.7 kb | Distal (>10kb) Multiome | 135 | |
| chr17:44,543,007–44,544,301 | 39.8 kb | Distal (>10kb) Multiome | 384 | |
| chr17:44,556,129–44,558,277 | 53.9 kb | Distal (>10kb) Multiome | 696 | |
| chr17:44,608,340–44,608,975 | 105.2 kb | Distal (>10kb) Multiome | 208 | |
| chr17:44,628,394–44,629,188 | 125.2 kb | Distal (>10kb) Multiome | 285 | |
| chr17:44,656,036–44,656,706 | 152.9 kb | Distal (>10kb) Multiome | 280 | |
| chr17:44,689,325–44,690,416 | 186.4 kb | Distal (>10kb) Multiome | 916 | |
| chr17:44,758,700–44,759,204 | 255.5 kb | Distal (>10kb) Multiome | 167 | |
| chr17:44,774,509–44,776,365 | 271.4 kb | Distal (>10kb) Multiome | 794 | |
| chr17:44,778,982–44,779,764 | 276.0 kb | Distal (>10kb) Multiome | 595 |
Genomic view of the GPATCH8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.