Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GPATCH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPATCH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPATCH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:32,971,721–32,972,560 | 109.1 kb | Distal (>10kb) Multiome | 796 | |
| chr19:33,022,514–33,023,071 | 58.4 kb | Distal (>10kb) Multiome | 102 | |
| chr19:33,032,077–33,032,955 | 48.7 kb | Distal (>10kb) Multiome | 217 | |
| chr19:33,064,252–33,065,504 | 16.3 kb | Distal (>10kb) Multiome | 603 | |
| chr19:33,080,776–33,081,465 | 90 bp | At TSS Multiome | 838 | |
| chr19:33,085,577–33,086,032 | 4.4 kb | Proximal (<10kb) | 38 | |
| chr19:33,124,582–33,125,060 | 43.7 kb | Distal (>10kb) Multiome | 321 | |
| chr19:33,176,278–33,177,966 | 96.0 kb | Distal (>10kb) Multiome | 1077 | |
| chr19:33,193,912–33,194,503 | 113.1 kb | Distal (>10kb) Multiome | 256 | |
| chr19:33,225,334–33,226,211 | 144.5 kb | Distal (>10kb) Multiome | 146 | |
| chr19:33,226,520–33,227,396 | 145.9 kb | Distal (>10kb) Multiome | 219 | |
| chr19:33,301,181–33,303,965 | 221.5 kb | Distal (>10kb) Multiome | 945 | |
| chr19:33,373,183–33,374,325 | 292.5 kb | Distal (>10kb) Multiome | 871 |
Genomic view of the GPATCH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.