This gene is located in a cluster of HLA-B-associated transcripts, which is included in the human major histocompatability complex III region. This gene encodes a protein which is thought to play a role in immunity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2010]
Transcription factors with Perturb-seq knockdown data for GPANK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPANK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPANK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:31,366,884–31,367,398 | 298.8 kb | Distal (>10kb) Multiome | 433 | |
| chr6:31,399,631–31,400,231 | 266.0 kb | Distal (>10kb) Multiome | 678 | |
| chr6:31,403,046–31,404,269 | 262.3 kb | Distal (>10kb) Multiome | 796 | |
| chr6:31,441,682–31,442,105 | 224.1 kb | Distal (>10kb) Multiome | 316 | |
| chr6:31,462,703–31,463,323 | 202.8 kb | Distal (>10kb) Multiome | 352 | |
| chr6:31,497,638–31,498,615 | 167.8 kb | Distal (>10kb) Multiome | 613 | |
| chr6:31,541,205–31,542,816 | 123.8 kb | Distal (>10kb) Multiome | 1073 | |
| chr6:31,546,485–31,547,136 | 119.1 kb | Distal (>10kb) Multiome | 589 | |
| chr6:31,547,301–31,547,742 | 118.2 kb | Distal (>10kb) Multiome | 762 | |
| chr6:31,580,713–31,581,330 | 84.8 kb | Distal (>10kb) Multiome | 745 | |
| chr6:31,619,744–31,621,435 | 45.3 kb | Distal (>10kb) Multiome | 1127 | |
| chr6:31,651,682–31,653,297 | 13.2 kb | Distal (>10kb) Multiome | 1113 | |
| chr6:31,660,325–31,660,941 | 5.1 kb | Proximal (<10kb) Multiome | 892 | |
| chr6:31,664,725–31,666,373 | 972 bp | At TSS Multiome | 1039 | |
| chr6:31,682,887–31,683,880 | 17.5 kb | Distal (>10kb) Multiome | 248 | |
| chr6:31,702,816–31,703,520 | 37.4 kb | Distal (>10kb) Multiome | 875 | |
| chr6:31,713,576–31,714,641 | 48.3 kb | Distal (>10kb) Multiome | 171 | |
| chr6:31,728,852–31,730,814 | 64.4 kb | Distal (>10kb) Multiome | 979 | |
| chr6:31,739,236–31,740,741 | 74.0 kb | Distal (>10kb) Multiome | 1043 | |
| chr6:31,766,045–31,766,778 | 100.6 kb | Distal (>10kb) Multiome | 351 | |
| chr6:31,795,097–31,796,366 | 130.1 kb | Distal (>10kb) Multiome | 979 | |
| chr6:31,806,162–31,807,183 | 141.1 kb | Distal (>10kb) Multiome HiCAR | 947 | |
| chr6:31,814,125–31,815,936 | 148.7 kb | Distal (>10kb) Multiome | 822 | |
| chr6:31,818,020–31,818,663 | 152.5 kb | Distal (>10kb) Multiome | 280 | |
| chr6:31,821,306–31,822,544 | 156.2 kb | Distal (>10kb) Multiome HiCAR | 714 | |
| chr6:31,826,770–31,828,135 | 161.7 kb | Distal (>10kb) Multiome HiCAR | 1000 | |
| chr6:31,834,277–31,835,371 | 168.9 kb | Distal (>10kb) Multiome HiCAR | 1085 | |
| chr6:31,862,148–31,864,173 | 197.1 kb | Distal (>10kb) Multiome HiCAR | 1118 | |
| chr6:31,896,965–31,898,037 | 231.7 kb | Distal (>10kb) Multiome | 654 | |
| chr6:31,901,114–31,902,643 | 236.4 kb | Distal (>10kb) Multiome | 826 | |
| chr6:31,958,527–31,959,598 | 293.2 kb | Distal (>10kb) Multiome | 953 |
Genomic view of the GPANK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.