Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for GPAA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GPAA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GPAA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:143,814,945–143,816,493 | 266.9 kb | Distal (>10kb) Multiome | 893 | |
| chr8:143,828,724–143,829,946 | 253.3 kb | Distal (>10kb) Multiome | 933 | |
| chr8:143,840,284–143,841,979 | 241.5 kb | Distal (>10kb) Multiome | 551 | |
| chr8:143,877,814–143,879,346 | 204.1 kb | Distal (>10kb) Multiome | 444 | |
| chr8:143,941,814–143,942,929 | 140.4 kb | Distal (>10kb) Multiome | 630 | |
| chr8:143,943,562–143,944,432 | 138.6 kb | Distal (>10kb) Multiome | 587 | |
| chr8:143,951,583–143,954,394 | 128.8 kb | Distal (>10kb) Multiome | 943 | |
| chr8:143,972,817–143,973,908 | 109.1 kb | Distal (>10kb) Multiome HiCAR | 436 | |
| chr8:143,976,288–143,977,568 | 105.6 kb | Distal (>10kb) Multiome HiCAR | 738 | |
| chr8:143,989,521–143,991,038 | 92.6 kb | Distal (>10kb) Multiome HiCAR | 596 | |
| chr8:144,049,063–144,051,761 | 32.0 kb | Distal (>10kb) Multiome | 342 | |
| chr8:144,060,259–144,061,087 | 21.9 kb | Distal (>10kb) Multiome | 727 | |
| chr8:144,078,142–144,079,235 | 4.0 kb | Proximal (<10kb) Multiome | 912 | |
| chr8:144,082,187–144,083,105 | 70 bp | At TSS Multiome | 763 | |
| chr8:144,094,454–144,095,491 | 12.3 kb | Distal (>10kb) Multiome | 798 | |
| chr8:144,103,485–144,105,242 | 21.7 kb | Distal (>10kb) Multiome | 1033 | |
| chr8:144,108,038–144,108,663 | 25.7 kb | Distal (>10kb) Multiome | 137 | |
| chr8:144,137,565–144,138,500 | 55.1 kb | Distal (>10kb) Multiome | 817 | |
| chr8:144,146,820–144,149,073 | 65.3 kb | Distal (>10kb) Multiome | 790 | |
| chr8:144,266,293–144,267,098 | 183.8 kb | Distal (>10kb) Multiome | 162 | |
| chr8:144,290,981–144,292,410 | 208.9 kb | Distal (>10kb) Multiome | 716 | |
| chr8:144,315,833–144,316,450 | 233.5 kb | Distal (>10kb) Multiome | 396 | |
| chr8:144,325,768–144,327,719 | 244.3 kb | Distal (>10kb) Multiome | 1016 | |
| chr8:144,331,281–144,333,847 | 249.3 kb | Distal (>10kb) Multiome | 406 | |
| chr8:144,336,102–144,339,119 | 254.2 kb | Distal (>10kb) Multiome | 922 | |
| chr8:144,353,907–144,355,227 | 271.9 kb | Distal (>10kb) Multiome | 280 | |
| chr8:144,358,142–144,359,070 | 275.9 kb | Distal (>10kb) Multiome | 719 | |
| chr8:144,369,349–144,369,916 | 287.1 kb | Distal (>10kb) Multiome | 204 | |
| chr8:144,372,497–144,372,883 | 290.1 kb | Distal (>10kb) Multiome | 160 | |
| chr8:144,372,993–144,375,084 | 291.3 kb | Distal (>10kb) Multiome | 903 |
Genomic view of the GPAA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.