Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Transcription factors with Perturb-seq knockdown data for GOT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GOT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GOT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:58,463,143–58,465,363 | 270.6 kb | Distal (>10kb) Multiome | 307 | |
| chr16:58,487,547–58,488,283 | 246.5 kb | Distal (>10kb) Multiome | 523 | |
| chr16:58,499,699–58,500,457 | 234.3 kb | Distal (>10kb) Multiome | 283 | |
| chr16:58,500,548–58,502,121 | 232.9 kb | Distal (>10kb) Multiome | 481 | |
| chr16:58,511,772–58,512,394 | 222.2 kb | Distal (>10kb) Multiome HiCAR | 355 | |
| chr16:58,515,027–58,516,681 | 218.8 kb | Distal (>10kb) Multiome | 1010 | |
| chr16:58,629,310–58,630,709 | 104.2 kb | Distal (>10kb) Multiome | 1050 | |
| chr16:58,684,159–58,685,101 | 49.6 kb | Distal (>10kb) Multiome | 695 | |
| chr16:58,733,415–58,734,721 | 84 bp | At TSS Multiome | 1031 | |
| chr16:58,756,000–58,756,694 | 22.2 kb | Distal (>10kb) Multiome | 352 | |
| chr16:58,862,372–58,863,064 | 128.5 kb | Distal (>10kb) Multiome | 145 |
Genomic view of the GOT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.