Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to act upstream of or within B cell differentiation. Located in nuclear body. [provided by Alliance of Genome Resources, Jul 2025]
Modules significantly affected by knockdown. ↑ Up = module upregulated upon KD; ↓ Down = module downregulated upon KD.
| Module | Dir | NES | #gRNA | padj | Bind | OR | padj (bind) |
|---|
| Submodule | Module | Dir | NES | #gRNA | Bind | OR | padj (bind) |
|---|
Genes likely regulated by GON4L through linked binding evidence in open chromatin. The chart ranks TF-linked genes by their mean Perturb-seq response to GON4L knockdown, with negative coefficients indicating downregulation and positive coefficients indicating upregulation upon knockdown.
Open chromatin elements (ATAC-seq) where GON4L has ChIP-seq or motif footprint binding evidence and which are linked to at least one target gene region.
| Element | Size | Linked genes |
|---|
Transcription factors with Perturb-seq knockdown data for GON4L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GON4L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GON4L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:155,562,014–155,563,482 | 294.3 kb | Distal (>10kb) Multiome | 909 | |
| chr1:155,609,731–155,610,295 | 247.1 kb | Distal (>10kb) Multiome | 503 | |
| chr1:155,688,087–155,689,328 | 168.4 kb | Distal (>10kb) Multiome | 838 | |
| chr1:155,745,339–155,745,870 | 111.6 kb | Distal (>10kb) Multiome | 505 | |
| chr1:155,806,537–155,807,073 | 50.4 kb | Distal (>10kb) Multiome | 15 | |
| chr1:155,856,932–155,857,529 | 34 bp | At TSS Multiome | 639 | |
| chr1:155,859,095–155,860,745 | 2.2 kb | Proximal (<10kb) Multiome | 632 | |
| chr1:155,910,686–155,911,579 | 54.2 kb | Distal (>10kb) Multiome | 691 | |
| chr1:155,934,107–155,934,787 | 77.3 kb | Distal (>10kb) Multiome | 872 | |
| chr1:155,976,727–155,977,187 | 119.7 kb | Distal (>10kb) Multiome | 316 | |
| chr1:155,977,296–155,979,264 | 121.5 kb | Distal (>10kb) Multiome | 698 | |
| chr1:156,020,469–156,021,128 | 163.7 kb | Distal (>10kb) Multiome | 558 | |
| chr1:156,052,923–156,055,358 | 197.7 kb | Distal (>10kb) Multiome | 1053 | |
| chr1:156,060,806–156,061,738 | 204.0 kb | Distal (>10kb) Multiome | 318 | |
| chr1:156,063,507–156,064,184 | 206.6 kb | Distal (>10kb) Multiome | 199 | |
| chr1:156,076,488–156,077,355 | 219.8 kb | Distal (>10kb) Multiome | 246 | |
| chr1:156,081,942–156,083,586 | 225.4 kb | Distal (>10kb) Multiome | 670 | |
| chr1:156,105,879–156,107,316 | 249.4 kb | Distal (>10kb) Multiome | 663 | |
| chr1:156,114,184–156,115,669 | 257.5 kb | Distal (>10kb) Multiome | 824 | |
| chr1:156,123,520–156,124,091 | 266.6 kb | Distal (>10kb) Multiome | 679 | |
| chr1:156,129,945–156,130,610 | 273.2 kb | Distal (>10kb) Multiome | 733 | |
| chr1:156,146,058–156,146,760 | 289.1 kb | Distal (>10kb) Multiome | 429 | |
| chr1:156,149,593–156,150,242 | 292.8 kb | Distal (>10kb) Multiome | 194 |
Genomic view of the GON4L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.