GNPNAT1

glucosamine-phosphate N-acetyltransferase 1 | FLJ10607, Gpnat1

Enables identical protein binding activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment and late endosome. [provided by Alliance of Genome Resources, Apr 2025]

Member of: DE-1 DE-1.22

Biological processes 10 terms

Golgi membrane (GO:0000139)UDP-N-acetylglucosamine biosynthetic process (GO:0006048)acyltransferase activity, transferring groups other than amino-acyl groups (GO:0016747)cytoplasm (GO:0005737)cytosol (GO:0005829)endosome membrane (GO:0010008)glucosamine 6-phosphate N-acetyltransferase activity (GO:0004343)glucosamine 6-phosphate N-acetyltransferase activity (GO:0004343)identical protein binding (GO:0042802)protein binding (GO:0005515)

Expression (TPM)

TFs regulating GNPNAT1 0 TFs

Transcription factors with Perturb-seq knockdown data for GNPNAT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GNPNAT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to GNPNAT1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GNPNAT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:52,551,688–52,554,284	239.0 kb	Distal (>10kb) Multiome	899
chr14:52,694,713–52,696,105	95.9 kb	Distal (>10kb) Multiome	749
chr14:52,706,745–52,707,707	84.5 kb	Distal (>10kb) Multiome	713
chr14:52,729,614–52,730,927	61.6 kb	Distal (>10kb) Multiome	803
chr14:52,790,881–52,792,384	25 bp	At TSS Multiome	1077
chr14:52,827,263–52,828,172	36.0 kb	Distal (>10kb) Multiome	103
chr14:52,835,079–52,835,883	43.7 kb	Distal (>10kb) Multiome	369
chr14:52,852,332–52,854,201	61.6 kb	Distal (>10kb) Multiome	475
chr14:52,950,305–52,952,252	159.6 kb	Distal (>10kb) Multiome HiCAR	746

Genome Browser

Genomic view of the GNPNAT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.