The protein encoded by this gene is an allosteric enzyme that catalyzes the reversible reaction converting D-glucosamine-6-phosphate into D-fructose-6-phosphate and ammonium. Variations of this gene have been reported to be associated with influencing body mass index and susceptibility to obesity. A pseudogene of this gene is located on chromosome 9. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Transcription factors with Perturb-seq knockdown data for GNPDA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GNPDA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GNPDA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:44,446,500–44,449,513 | 277.6 kb | Distal (>10kb) Multiome | 609 | |
| chr4:44,677,872–44,679,014 | 48.1 kb | Distal (>10kb) Multiome | 817 | |
| chr4:44,725,729–44,727,272 | 65 bp | At TSS Multiome | 859 | |
| chr4:44,863,107–44,864,499 | 137.5 kb | Distal (>10kb) Multiome | 212 | |
| chr4:46,586,321–46,587,060 | 1860.2 kb | Distal (>10kb) Multiome HiCAR | 77 |
Genomic view of the GNPDA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.